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KMID : 0613820050150030461
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Journal of Life Science
2005 Volume.15 No. 3 p.461 ~ p.467
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Protective Effect of DWP-04 Against Hepatotoxicity Induced by D-galactosamine
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Lee Jung-Hee
Chi Sang-Cheol
Kim Seck-Hwan
Shin Young-Ho
Choi Jong-Won
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Abstract
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This study was conducted to investigate the biological activity and hepatoprotective effect of DWP-04 [DDB : selenium yeast : glutathione (31.1 : 6.8 : 62.1(w/w/w)] in D-galactosamine (GaIN) intoxicated rats. The DWP-04 (50, 100 or 200 ㎎/㎏) or its vehicle was orally administered everyday before the start of GaIN injection (400 ㎎/㎏, ip) for two weeks and animal decapitated for 24 hrs after GaINinjected. The activities of serum enzymes, markers of liver function, were increased in the GaIN group compared to normal group and significantly lowered in the DWP-04 pretreated group than in the GaIN group. Hepatic lipid peroxide level and activities of phase 1 enzymes were significantly higher than those of GaIN group compared to normal group and lower in the DWP-04 pretreated group than in the GaIN group, and phase II enzyme activities in liver were lower in the GaIN group than in the normal group and were increased in the DWP-04 pretreated group than in the GaIN group. Total hepatic glutathione content and glutathione biosynthesis enzymes were lower in the GaIN group than in the normal group and were increased in the DWP-04 pretreated group than in the GaIN group. Therefore, the current results indicated that DWP-04 administration alleviated the GaIN-induced adverse effect through enhancing the antioxidant enzyme activities.
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